Piperidin-4-ol → HCID 23144751, compound

HRID 1967763Notes

Reaction equation

HRID 1967763 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[CH2:9][C:10]1[CH:15]=[C:14]([C:16]([NH:18][C:19]2[S:20][C:21]([C:29]3[CH:34]=[CH:33][N:32]=[CH:31][CH:30]=3)=[C:22]([C:24]3[O:25][CH:26]=[CH:27][CH:28]=3)[N:23]=2)=[O:17])[CH:13]=[CH:12][N:11]=1>>[O:25]1[CH:26]=[CH:27][CH:28]=[C:24]1[C:22]1[N:23]=[C:19]([NH:18][C:16]([C:14]2[CH:13]=[CH:12][N:11]=[C:10]([CH2:9][N:5]3[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]3)[CH:15]=2)=[O:17])[S:20][C:21]=1[C:29]1[CH:30]=[CH:31][N:32]=[CH:33][CH:34]=1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 23144585HCID 23144585, compound

Product 1

HCID 23144751HCID 23144751, compoundYield 53%

Procedure

In a manner similar to that in Example 108, by using 4-hydroxypiperidine in place of imidazole, the entitled Compound 111 (92.0 mg, 53%) was obtained from Compound 107.

Sources & evidence

ORD record
ord-e91cee4cba06432d8c9c7c7edf9998c7
Source dataset
uspto-grants-2013_04
Patent number
US08420827B2

Reaction notes

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