HCID 23144087, compound → HCID 23144278, compound

HRID 1967784Notes

Reaction equation

HRID 1967784 reaction equation
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:19][C:20]([C:22]2[CH:27]=[CH:26][N:25]=[C:24]([O:28]CC3C=CC(OC)=CC=3)[CH:23]=2)=[O:21])[S:9][C:10]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)=[O:12]>FC(F)(F)C(O)=O>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:7]=[C:8]([NH:19][C:20]([C:22]2[CH:27]=[CH:26][NH:25][C:24](=[O:28])[CH:23]=2)=[O:21])[S:9][C:10]=1[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][N:14]=1)=[O:12]

Participants

3

Reactant 1

HCID 23144087HCID 23144087, compound

Product 1

HCID 23144278HCID 23144278, compoundYield 67.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Compound 213 (912 mg, 1.78 mmol) was dissolved in trifluoroacetic acid (3.6 mL), followed by stirring at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the resulting residue was reslurried with ethyl acetate to afford the entitled Compound 231 (469 mg, 67%) as a pale yellow solid.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-edf17ffd304747da810d2e12ff54ba5f
Source dataset
uspto-grants-2013_04
Patent number
US08420827B2

Reaction notes

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