Hexane → HCID 23144358, compound

HRID 1967874Notes

Reaction equation

HRID 1967874 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]([C:9]1[S:13][C:12]([NH2:14])=[N:11][C:10]=1[C:15]1[O:16][CH:17]=[CH:18][CH:19]=1)=[O:8].[C:20](N1C=CN=C1)(N1C=CN=C1)=[O:21].CCCCCC>ClCCl>[O:16]1[CH:17]=[CH:18][CH:19]=[C:15]1[C:10]1[N:11]=[C:12]([N:14]=[C:20]=[O:21])[S:13][C:9]=1[C:7]([C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][N:1]=1)=[O:8]

Participants

5

Reactant 3

HCID 8058HexaneHCID 682631,1'-CarbonyldiimidazoleHCID 23144251HCID 23144251, compound

Product 1

HCID 23144358HCID 23144358, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 186 (200 mg, 0.737 mmol) was suspended in dichloromethane (15 mL), and carbonyldiimidazole (179 mg, 1.11 mmol) was added thereto at room temperature, followed by stirring at room temperature for 2 hours. Hexane (7.5 mL) was added to the reaction mixture, and the precipitated solid was collected by filtration to afford the entitled Compound y (133 mg, 61%) as a brown solid.

Workup

  1. customat room temperature
  2. filtrationthe precipitated solid was collected by filtration

Sources & evidence

ORD record
ord-918870c597104de7a261382db46cf970
Source dataset
uspto-grants-2013_04
Patent number
US08420827B2

Reaction notes

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