Trifluoroacetic acid → 390382-13-5

HRID 1968361Notes

Reaction equation

HRID 1968361 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].C(=O)(O)O.[NH2:12][C:13]([NH2:15])=[NH:14]>O>[O-:5][C:3]([C:2]([F:7])([F:6])[F:1])=[O:4].[NH2:14][C:13]([NH2:15])=[NH2+:12]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 286947Carbonic acid-guanidine (1:1)

Product 1

HCID 129729295390382-13-5

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

Trifluoroacetic acid (50.0 ml, 74.0 g, 649 mmol) was added to 500 ml of distilled water in a 4-liter beaker with stirring. Guanidine carbonate (58.5 g, 324.5 mmol) was added at room temperature in portions with stirring as to avoid bubbling over the sides of the beaker due to the evolution of carbon dioxide. The reaction was stirred at room temperature for 2 hours. The water was removed in vacuo with heating to approximately 90° C. for 4 hours. The product was recovered as a white crystalline solid.

Workup

  1. stirringwith stirring as
  2. customto avoid bubbling over the sides of the beaker due to the evolution of carbon dioxide
  3. stirringThe reaction was stirred at room temperature for 2 hours
  4. customThe water was removed in vacuo
  5. customThe product was recovered as a white crystalline solid

Sources & evidence

ORD record
ord-0c5b08fa01a1450c8463885752b10087
Source dataset
uspto-grants-2013_04
Patent number
US08425702B2

Reaction notes

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