反应详情

A solution of 6-(2-Chloro-benzoimidazol-1-yl)-pyrimidin-4-ylamine (15 mg, 0.056 mmol), 3-amino-4-methyl-N-[4-(2-methyl-imidazol-1-yl)-3-trifluoromethyl-phenyl]-benzamide (22 mg, 0.059 mmol), and MeSO3H (11.0 μL, 0.17 mmol) in 1,3-dimethyl-2-imidazolidinone (0.2 ml) is heated at 80° C. After stirring for overnight, the reaction mixture is cooled to room temperature. Purification by reverse-phase LC-MS afforded the title compound: 1H NMR 600 MHz (DMSO-d6) δ 11.50-11.00 (bs, 1H), 10.90 (s, 1H), 9.02 (s, 1H), 8.57 (s, 1H), 8.55 (d, J=2.0 Hz, 1H), 8.37 (dd, J=8.2, 2.0 Hz 1H), 7.92 (s, 1H), 7.87 (d, J=8.2 Hz, 1H), 7.81 (d, J=2.0 Hz, 1H), 7.70 (s, 1H), 7.69 (s, 1H), 7.55-7.46 (m, 4H), 7.87 (d, J=8.2 Hz, 1H), 7.27 (t, J=8.2 Hz, 1H), 7.22 (t, J=8.2 Hz, 1H), 2.46 (s, 3H), 2.41 (s, 3H); MS m/z 584.2 (M+1).

1. customPurification by reverse-phase LC-MS