反应详情

A solution of 6-(2-chloro-benzoimidazol-1-yl)-pyrimidin-4-ylamine (110 mg, 0.45 mmol), 2-methyl-4-nitro-phenylamine (103 mg, 0.68 mmol), and MeSO3H (58.0 μL, 0.9 mmol) in 1,3-dimethyl-2-imidazolidinone (0.2 ml) is heated at 90° C. After stirring for 2 hours, the reaction mixture is cooled to room temperature and is treated with water (5 mL). Solid is collected via filtration and further purified by flash chromatography on silica gel (0% MeOH/Dichloromethane to 10% MeOH/Dichloromethane gradient). The title compound is obtained as white powder.

1. filtrationSolid is collected via filtration
2. customfurther purified by flash chromatography on silica gel (0% MeOH/Dichloromethane to 10% MeOH/Dichloromethane gradient)