Dimethylamine → HCID 16753949, compound

HRID 1968435Notes

Reaction equation

HRID 1968435 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:12])=[C:6]([S:8](Cl)(=[O:10])=[O:9])[CH:7]=1.[CH3:13][NH:14][CH3:15]>C1COCC1.CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:12])=[C:6]([S:8]([N:14]([CH3:15])[CH3:13])(=[O:10])=[O:9])[CH:7]=1

Participants

5

Reactant 2

HCID 674DimethylamineHCID 1362865-Fluoro-2-methylbenzenesulphonyl chloride

Product 1

HCID 16753949HCID 16753949, compoundYield 99%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of 5-fluoro-2-methylbenzene sulfonylchloride (2.1 mL, 14.3 mmol) in THF (18 mL) and 2 M dimethylamine in methanol (18 mL), was stirred at room temperature for 0.5 h. The resulting mixture was concentrated under reduced pressure to give a crude product as a mixture of white solid and colourless oil. The crude product was purified by column (30% EtOAc in Hexane) to give the titled compound as a colourless oil (3.09 g, 99% yield).

Workup

  1. concentrationThe resulting mixture was concentrated under reduced pressure
  2. customto give a crude product
  3. additionas a mixture of white solid and colourless oil
  4. customThe crude product was purified by column (30% EtOAc in Hexane)

Sources & evidence

ORD record
ord-7d2f7be7e28d4ef5be831c915c690971
Source dataset
uspto-grants-2013_04
Patent number
US08426405B2

Reaction notes

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