反应详情

3-Hydroxy-8-nitrobenzo[c]chromen-6-one (Reference Compound No. 1-1-(2), 52.01 g, 202 mmol) was dissolved in methanol (150 mL)-N,N-dimethylformamide (600 mL), 10% palladium on charcoal (5.00 g) was added thereto, and then the reaction mixture was stirred under hydrogen atmosphere (3 kgf/cm2) at room temperature overnight. After the unsoluble materials were filtered, the methanol was removed under reduced pressure. Water (2 L) was added to the residue. The precipitated solid was filtered and dried at 90° C. under reduced pressure to give the titled reference compound (44.02 g) as a pale yellow solid.

1. additionwas added
2. filtrationAfter the unsoluble materials were filtered
3. customthe methanol was removed under reduced pressure
4. additionWater (2 L) was added to the residue
5. filtrationThe precipitated solid was filtered
6. customdried at 90° C. under reduced pressure