HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-nitro-1H-pyrazole | HCID 16376 | — |
| Reactant | 2-chloro-N,N-dimethylacetamide | HCID 75886 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N,N-dimethyl-2-(4-nitro-1H-pyrazol-1-yl)acetamide | HCID 60729245 | — |
Reaction Steps
A suspension of 4-nitro-1H-pyrazole (0.4 g, 3.54 mmol), 2-chloro-N,N-dimethylacetamide (0.546 ml, 5.31 mmol) and potassium carbonate (0.733 g, 5.31 mmol) in 18 ml acetone was refluxed for 6 hours. The cooled suspension was filtered with acetone washes and the concentrated residue was flash chromatographed (50 mm, 3% methanol in CH2Cl2) to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426408B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-6311ee7d652a40a7b61b4583e234d152 |
| Source note | uspto-grants-2013_04 |