反应详情

A suspension of 4-nitro-1H-pyrazole (0.4 g, 3.54 mmol), 2-chloro-N,N-dimethylacetamide (0.546 ml, 5.31 mmol) and potassium carbonate (0.733 g, 5.31 mmol) in 18 ml acetone was refluxed for 6 hours. The cooled suspension was filtered with acetone washes and the concentrated residue was flash chromatographed (50 mm, 3% methanol in CH2Cl2) to afford the title compound.

1. temperaturewas refluxed for 6 hours
2. filtrationThe cooled suspension was filtered with acetone washes
3. customchromatographed (50 mm, 3% methanol in CH2Cl2)