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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968559Generated: October 30, 2026

Hydrochloric Acid → HCID 68746221, compound

https://huagongshe.com/reaction/1968559

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 57391651HCID 57391651—
SolventTetrahydrofuranHCID 8028—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 68746221HCID 6874622198%

Reaction Steps

To a solution of methyl-2-{2-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-pyrimidin-4-yl}-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (25 mg, 0.037 mmol) in tetrahydrofuran (1 mL), 4M HCl in dioxane (0.4 mL) were added. The solution was stirred at room temperature over night. The solvent was evaporated under vacuo to yield 22 mg (98%) of the title compound as a beige powder.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08426417B2
Source datasetuspto-grants-2013_04
ORD IDord-df420532d8e546a89e4a4be26348823b
Source noteuspto-grants-2013_04