Hydrochloric Acid → HCID 68746221, compound

HRID 1968559Notes

Reaction equation

HRID 1968559 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2[N:14]([CH3:42])[C:15]([C:17]3[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]4[CH:29]=[C:28]([N:30]5[CH2:35][CH2:34][N:33]([CH3:36])[CH2:32][CH2:31]5)[CH:27]=[CH:26][C:25]=4[O:37][C:38]([F:41])([F:40])[F:39])[N:18]=3)=[CH:16][C:10]=2[C:9]1=[O:43])=O)(C)(C)C.[ClH:44]>O1CCCC1.O1CCOCC1>[ClH:44].[CH3:42][N:14]1[C:11]2[CH2:12][CH2:13][NH:8][C:9](=[O:43])[C:10]=2[CH:16]=[C:15]1[C:17]1[CH:22]=[CH:21][N:20]=[C:19]([NH:23][C:24]2[CH:29]=[C:28]([N:30]3[CH2:31][CH2:32][N:33]([CH3:36])[CH2:34][CH2:35]3)[CH:27]=[CH:26][C:25]=2[O:37][C:38]([F:40])([F:41])[F:39])[N:18]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57391651HCID 57391651, compound

Product 1

HCID 68746221HCID 68746221, compoundYield 98%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of methyl-2-{2-[5-(4-methyl-piperazin-1-yl)-2-trifluoromethoxy-phenylamino]-pyrimidin-4-yl}-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester (25 mg, 0.037 mmol) in tetrahydrofuran (1 mL), 4M HCl in dioxane (0.4 mL) were added. The solution was stirred at room temperature over night. The solvent was evaporated under vacuo to yield 22 mg (98%) of the title compound as a beige powder.

Workup

  1. customThe solvent was evaporated under vacuo

Sources & evidence

ORD record
ord-df420532d8e546a89e4a4be26348823b
Source dataset
uspto-grants-2013_04
Patent number
US08426417B2

Reaction notes

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