HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromobenzyl bromide → Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromobenzyl bromide | HCID 76965 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Ethyl 4-(piperazin-1-yl)benzoate | HCID 2761178 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Ethyl 4-(4-(2-Bromobenzyl)piperazin-1-yl)benzoate | HCID 16109102 | — |
Reaction Steps
A solution of EXAMPLE 1B (23.43 g, 100.0 mmol), 2-bromobenzyl bromide (26.24 g, 105.0 mmol) and diisopropylethylamine (20.94 mL, 120 0 mmol) in acetonitrile (200 mL) was stirred at room temperature for two hours. The resulting precipitate was collected by filtration to give the title compound, which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426422B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-a3ada4b2bbc4464d938dfb17e824f994 |
| Source note | uspto-grants-2013_04 |