反应详情

Ethyl 2-bromo-3-methylbutanoate (2.2 g, 10.52 mmol) in ethanol (15 mL) was added dropwise over a period of 2.5 hours to a stirred refluxing solution of ethane-1,2-diamine (13.2 mL, 197 mmol) in ethanol (60 mL). The mixture was heated for another 2.5 hours, and sodium ethoxide in ethanol (21% by wt) (4.0 mL, 10.80 mmol) was added and the mixture was heated for another 90 minutes. The reaction was then cooled and concentrated. After trituration with ether, the title compound was used in the next step without further purification.

1. temperatureThe mixture was heated for another 2.5 hours
2. temperaturethe mixture was heated for another 90 minutes
3. temperatureThe reaction was then cooled
4. concentrationconcentrated
5. customAfter trituration with ether, the title compound was used in the next step without further purification