HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968619Generated: October 30, 2026
Ammonium Hydroxide → Isoquinoline-5-sulfonamide
https://huagongshe.com/reaction/1968619
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonium Hydroxide | HCID 14923 | — |
| Reactant | 5-Isoquinolinesulfonyl chloride | HCID 3371655 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Isoquinoline-5-sulfonamide | HCID 9837177 | — |
Reaction Steps
Isoquinoline-5-sulfonyl chloride (528 mg) was dissolved in tetrahydrofuran (8 mL), cooled to 0° C., then concentrated NH4OH (0.7 mL) was added and the reaction was allowed to come to room temperature overnight. The product was filtered off, washed with water, and dried under vacuum.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08426422B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-b986f518ab744c569fec14f6678d2a4b |
|---|
| Source note | uspto-grants-2013_04 |
|---|
