Ammonium Hydroxide → Isoquinoline-5-sulfonamide

HRID 1968619Notes

Reaction equation

HRID 1968619 reaction equation
[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11](Cl)(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1.[NH4+:15].[OH-]>O1CCCC1>[CH:1]1[C:10]2[CH:9]=[CH:8][CH:7]=[C:6]([S:11]([NH2:15])(=[O:13])=[O:12])[C:5]=2[CH:4]=[CH:3][N:2]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 33716555-Isoquinolinesulfonyl chloride

Product 1

HCID 9837177Isoquinoline-5-sulfonamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

Isoquinoline-5-sulfonyl chloride (528 mg) was dissolved in tetrahydrofuran (8 mL), cooled to 0° C., then concentrated NH4OH (0.7 mL) was added and the reaction was allowed to come to room temperature overnight. The product was filtered off, washed with water, and dried under vacuum.

Workup

  1. filtrationThe product was filtered off
  2. washwashed with water
  3. customdried under vacuum

Sources & evidence

ORD record
ord-b986f518ab744c569fec14f6678d2a4b
Source dataset
uspto-grants-2013_04
Patent number
US08426422B2

Reaction notes

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