Ammonia → HCID 86643508, compound

HRID 1968620Notes

Reaction equation

HRID 1968620 reaction equation
[CH2:1]([N:3]([C:10]1[CH:19]=[CH:18][CH:17]=[C:16]2[C:11]=1[CH:12]=[CH:13][CH:14]=[C:15]2[S:20](Cl)(=[O:22])=[O:21])[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])[CH3:2].[NH3:24]>O1CCCC1>[CH2:1]([N:3]([C:10]1[C:11]2[C:16](=[C:15]([S:20](=[O:22])(=[O:21])[NH2:24])[CH:14]=[CH:13][CH:12]=2)[CH:17]=[CH:18][CH:19]=1)[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 2758932HCID 2758932, compound

Product 1

HCID 86643508HCID 86643508, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

5-(N-ethyl-2,2,2-trifluoroacetamido)naphthalene-1-sulfonyl chloride (100 mg) was dissolved in tetrahydrofuran (1.0 mL), cooled to 0° C., then concentrated ammonia (0.11 mL) was added. The reaction was stirred at 0° C. for 3 hours, then concentrated and partitioned between water and ethyl acetate. The organic layer was dried over Na2SO4, filtered, and concentrated to give the title compound.

Workup

  1. concentrationconcentrated
  2. custompartitioned between water and ethyl acetate
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-27ffeb68260443e085a5d580011c55a5
Source dataset
uspto-grants-2013_04
Patent number
US08426422B2

Reaction notes

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