反应详情

A mixture of N-(3-ethynylphenyl)-7-nitroquinazolin-4-amine (2.0 g, 6.89 mmol), SnCl2 (5.0 g, 26.37 mmol), and ethyl acetate (50 mL) was refluxed for 3 h, and then subeject to extraction with ethyl acetate (20 mL) twice. The combined organic layers were washed with brine (20 mL) twice, dried over Na2SO4, and concentrated in vacuo to afford 1.6 g (86%) of N4-(3-ethynylphenyl)quinazoline-4,7-diamine as a yellow solid.

1. temperaturewas refluxed for 3 h
2. extractionsubeject to extraction with ethyl acetate (20 mL) twice
3. washThe combined organic layers were washed with brine (20 mL) twice
4. dry with materialdried over Na2SO4
5. concentrationconcentrated in vacuo