反应详情

N-(3-ethynylphenyl)-7-nitroquinazolin-4-amine (2.0 g, 6.89 mmol), SnCl2 (5.0 g, 26.37 mmol), and ethyl acetate (50 mL) was refluxed for 3 h. The mixture was subjected to extraction with ethyl acetate (20 mL). The combined organic layers were washed with brine (20 mL×2), dried over Na2SO4, and concentrated in vacuo to afford 1.6 g (86%) of N4-(3-ethynylphenyl)quinazoline-4,7-diamine as a yellow solid.

1. extractionThe mixture was subjected to extraction with ethyl acetate (20 mL)
2. washThe combined organic layers were washed with brine (20 mL×2)
3. dry with materialdried over Na2SO4
4. concentrationconcentrated in vacuo