Formamide → HCID 178518022, compound

HRID 1968648Notes

Reaction equation

HRID 1968648 reaction equation
[NH2:1][C:2]1[CH:10]=[C:9]([F:11])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].[CH:12]([NH2:14])=O>>[F:11][C:9]1[CH:10]=[C:2]2[C:3]([C:4]([OH:5])=[N:14][CH:12]=[N:1]2)=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 713FormamideHCID 27249674-Fluoroanthranilic acid

Product 1

HCID 178518022HCID 178518022, compoundYield 78%

Conditions

Temperature
150 °C

Procedure

2-amino-4-fluorobenzoic acid (1.55 g, 10 mmol) was dissolved into formamide (5 mL) and stirred at 150° C. for 6 h. The mixture was cooled to room temperature with stirring. The precipitate was filtered out and washed with diethyl ether to give 1.3 g of 7-fluoroquinazolin-4-ol (78%).

Workup

  1. temperatureThe mixture was cooled to room temperature
  2. stirringwith stirring
  3. filtrationThe precipitate was filtered out
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-03bee2ba47bc4732b576827c8608b85d
Source dataset
uspto-grants-2013_04
Patent number
US08426430B2

Reaction notes

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