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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1968814Generated: November 3, 2026

HCID 58625122, compound → 3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

https://huagongshe.com/reaction/1968814

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 58625122HCID 58625122—
SolventDichloromethaneHCID 6344—
SolventTrifluoroacetic acidHCID 6422—
Product3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamineHCID 58625123—

Reaction Steps

A mixture of {3-propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-yl}-carbamic acid tert-butyl ester (0.0001 mol) in 10% TFA in DCM (6 mL) was stirred in a reaction vial for 1 hour at room temperature and then the solvent was evaporated. The obtained residue was crystallized from CH3CN, and then the desired product was filtered off, washed with diisopropyl ether and dried under vaccum to yield the title compound as a solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08426429B2
Source datasetuspto-grants-2013_04
ORD IDord-0f31e907521d40a3bfbaaf2087f8997b
Source noteuspto-grants-2013_04