HCID 58625122, compound → 3-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

HRID 1968814Notes

Reaction equation

HRID 1968814 reaction equation
C(OC(=O)[NH:7][C:8]1[N:17]([CH2:18][CH2:19][CH3:20])[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][CH2:29][C:30]4[C:35]([CH3:36])=[CH:34][C:33]([CH3:37])=[CH:32][C:31]=4[CH3:38])[CH:23]=3)[CH:14]=2)[N:9]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH2:18]([N:17]1[CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([NH:28][CH2:29][C:30]4[C:31]([CH3:38])=[CH:32][C:33]([CH3:37])=[CH:34][C:35]=4[CH3:36])[CH:23]=3)[CH:14]=2)[N:9]=[C:8]1[NH2:7])[CH2:19][CH3:20]

Participants

4

Reactant 1

HCID 58625122HCID 58625122, compound

Product 1

HCID 586251233-Propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-ylamine

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of {3-propyl-6-[3-(2,4,6-trimethyl-benzylamino)-phenoxy]-3,4-dihydro-quinazolin-2-yl}-carbamic acid tert-butyl ester (0.0001 mol) in 10% TFA in DCM (6 mL) was stirred in a reaction vial for 1 hour at room temperature and then the solvent was evaporated. The obtained residue was crystallized from CH3CN, and then the desired product was filtered off, washed with diisopropyl ether and dried under vaccum to yield the title compound as a solid.

Workup

  1. customthe solvent was evaporated
  2. customThe obtained residue was crystallized from CH3CN
  3. filtrationthe desired product was filtered off
  4. washwashed with diisopropyl ether
  5. customdried under vaccum

Sources & evidence

ORD record
ord-0f31e907521d40a3bfbaaf2087f8997b
Source dataset
uspto-grants-2013_04
Patent number
US08426429B2

Reaction notes

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