Hydrochloric Acid → Hydrochloric Acid

HRID 1968869Notes

Reaction equation

HRID 1968869 reaction equation
C([O:5][C:6]([C@@H:8]1[CH2:10][C@H:9]1[C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[N:12]=1)=[O:7])(C)(C)C.[ClH:18]>C(Cl)Cl.O1CCOCC1>[F:17][C:13]1[N:12]=[C:11]([C@@H:9]2[CH2:10][C@H:8]2[C:6]([OH:7])=[O:5])[CH:16]=[CH:15][CH:14]=1.[ClH:18]

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 67114136HCID 67114136, compound

Product 2

HCID 313Hydrochloric AcidYield 79%HCID 67114406HCID 67114406, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of trans-2-(6-fluoro-pyridin-2-yl)-cyclopropanecarboxylic acid t-butyl ester (165 mg, 0.7 mmol) in DCM (3 mL) was added HCl in dioxane (4 M, 10 mL). The resulting mixture was stirred at rt for 3 h. The mixture was then concentrated to give the desired product as HCl salt (120 mg, 79%). MS (M−H 181).

Workup

  1. concentrationThe mixture was then concentrated

Sources & evidence

ORD record
ord-7ea9e0fb5e794237a1f56752072c489b
Source dataset
uspto-grants-2013_04
Patent number
US08426414B2

Reaction notes

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