Diethyl Ether → HCID 178468176, compound

HRID 1968967Notes

Reaction equation

HRID 1968967 reaction equation
[CH2:1]([O:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([N:10]2C(=O)C3=CC=CC=C3C2=O)[CH2:6][CH2:5]1)[CH3:2].O.NN.C(OCC)C>C(O)C.CO>[CH2:1]([O:3][C@H:4]1[CH2:9][CH2:8][C@H:7]([NH2:10])[CH2:6][CH2:5]1)[CH3:2]

Participants

6

Reactant 3

HCID 3283Diethyl EtherHCID 24654Hydrazine hydrate (1:1)HCID 178468173HCID 178468173, compound

Product 1

HCID 178468176HCID 178468176, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Procedure

A solution of trans-N-(4-ethoxycyclohexyl)phthalimide (D64, 16.35 g), hydrazine hydrate (12 mL) in ethanol (300 mL) and methanol (200 mL) was stirred at reflux for 3 hours. The solvent was removed to give a slurry, which was treated with diethyl ether and filtered. The filtrate was evaporated to afford the title compound as a viscous oil contaminated with ether (8.16 g).

Workup

  1. temperatureat reflux for 3 hours
  2. customThe solvent was removed
  3. customto give a slurry, which
  4. filtrationfiltered
  5. customThe filtrate was evaporated

Sources & evidence

ORD record
ord-b8c2ac66aadd4d8dbc26e47e9372fadd
Source dataset
uspto-grants-2013_04
Patent number
US08426443B2

Reaction notes

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