Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Ethyl-1-methyl-4-oxopiperidin-1-ium iodide | HCID 11097568 | — |
| Reactant | HCID 178468176 | HCID 178468176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178468171 | HCID 178468171 | 90.1% |
Reaction Steps
A mixture of 1-ethyl-4-piperidone methiodide (D9, 27 g), trans-4-ethoxycyclohexylamine (D65, 8.16 g, 0.065 mol), potassium carbonate (13.5 g), water (100 mL), and ethanol (200 mL) was heated for 3 hours at 80° C., then cooled overnight. The mixture was partitioned with aqueous sodium bicarbonate and dichloromethane. The dichloromethane layer was separated, washed with brine and solvent removed to give the title compound as an amber coloured oil (13.2 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08426443B2 |
|---|
| Source dataset | uspto-grants-2013_04 |
|---|
| ORD ID | ord-8710b413932b4bb89c7e87814a700241 |
|---|
| Source note | uspto-grants-2013_04 |
|---|
