HCID 2755516, compound → HCID 14520121, compound

HRID 1968992Notes

Reaction equation

HRID 1968992 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([N+:11]([O-])=O)[CH:5]=1>C(O)C.[Pt](=O)=O>[NH2:11][C:6]1[CH:5]=[C:4]([CH2:3][O:2][CH3:1])[CH:9]=[CH:8][C:7]=1[OH:10]

Participants

4

Reactant 1

HCID 2755516HCID 2755516, compound

Product 1

HCID 14520121HCID 14520121, compoundYield 85%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 702EthanolSolvent

Procedure

A mixture of 4-[(methyloxy)methyl]-2-nitrophenol D119 (0.72 g, 3.93 mmol) and platinum (IV) oxide (0.089 g, 0.393 mmol) in ethanol (15 mL) was stirred under an atmosphere of hydrogen for 16 hr. The catalyst was removed by filtration through celite and the filtrate concentrated to dryness in vacuo to afford the title compound as a green/brown solid 0.51 g, 85%.

Workup

  1. customThe catalyst was removed by filtration through celite
  2. concentrationthe filtrate concentrated to dryness in vacuo

Sources & evidence

ORD record
ord-89eb8d5cade642a3a163018b76b86476
Source dataset
uspto-grants-2013_04
Patent number
US08426443B2

Reaction notes

Loading…