反应详情

To a stirred solution of 4-methyl-2-nitrobenzoic acid (5 g, 27.6 mmol) in tetrahydrofuran (THF) (27 mL) was added borane tetrahydrofuran complex (35.9 mL, 35.9 mmol) and the mixture stirred at reflux for 3 hours. After cooling, the reaction mixture was extracted with water and DCM. The combined organic layers were dried over MgSO4 and then evaporated to dryness to give the alcohol (D139) as a pale yellow solid (4.52 g, 98%) which was used without further purification.

1. temperatureat reflux for 3 hours
2. temperatureAfter cooling
3. extractionthe reaction mixture was extracted with water and DCM
4. dry with materialThe combined organic layers were dried over MgSO4
5. customevaporated to dryness