HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1969014Generated: October 30, 2026
3'-Hydroxyphenylacetic acid → [3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid
https://huagongshe.com/reaction/1969014
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 3'-Hydroxyphenylacetic acid | HCID 12122 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 5-Bromo-2-fluorobenzaldehyde | HCID 736327 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid | HCID 58237510 | — |
Reaction Steps
3-Hydroxyphenylacetic acid (1.34 g, 8.8 mmol) and 5-bromo-2-fluorobenzaldehyde (1.78 g, 8.8 mmol) were combined in DMF (30 mL) at room temperature. Sodium hydride (60% in mineral oil; 0.72 g, 18.0 mmol) was added, and the reaction was stirred at 70° C. for 2 hours. Aqueous work-up yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08426449B2 |
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| Source dataset | uspto-grants-2013_04 |
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| ORD ID | ord-1b02aa2f91f44396b82a40aac6e06efa |
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| Source note | uspto-grants-2013_04 |
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