HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenethylamine → {3-[4-Bromo-2-(phenethylamino-methyl)-phenoxy]-phenyl}-acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenethylamine | HCID 1001 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | [3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid | HCID 58237510 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | {3-[4-Bromo-2-(phenethylamino-methyl)-phenoxy]-phenyl}-acetic acid | HCID 58288481 | — |
Reaction Steps
[3-(4-Bromo-2-formyl-phenoxy)-phenyl]-acetic acid (0.4 g, 1.23 mmol), 2-phenylethylamine (0.16 mL, 1.23 mmol), sodium cyanoborohydride (0.189 g, 3.0 mmol), and acetic acid (2 drops) were combined in CH2Cl2 and stirred at room temperature for 10 minutes. Aqueous work-up yielded the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08426449B2 |
| Source dataset | uspto-grants-2013_04 |
| ORD ID | ord-e6b213778c234b7c931aca04f55476af |
| Source note | uspto-grants-2013_04 |