Benzyl chloroformate → HCID 58288491, compound

HRID 1969027Notes

Reaction equation

[CH3:1][O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][NH:20][C@@H:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH2:22]2)[CH:6]=1.Cl[C:32]([O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)=[O:33]>>[CH3:1][O:2][C:3](=[O:30])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([Br:18])=[CH:14][C:13]=2[CH2:19][N:20]([C:32]([O:34][CH2:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)=[O:33])[C@@H:21]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH2:23][CH2:22]2)[CH:6]=1

Participants

Reactant 2

HCID 10387Benzyl chloroformate

HCID 58288504HCID 58288504, compound

Product 1

HCID 58288491HCID 58288491, compound

Procedure

Prepared according to the procedure described in Example 3, Step 3, using the following starting materials: {3-[4-bromo-2-((S)-indan-1-ylaminomethyl)-phenoxy]-phenyl}-acetic acid methyl ester and benzyl chloroformate.

Workup

customPrepared

Sources & evidence

ORD record: ord-2ecbbe28422d4f77aaab37857e2d1993
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08426449B2

Reaction notes

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