Methylamine → [3-(2-Methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

HRID 1969051Notes

Reaction equation

HRID 1969051 reaction equation
[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22]=O)[CH:6]=1.[CH3:25][NH2:26]>>[CH3:1][O:2][C:3](=[O:24])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:26][CH3:25])[CH:6]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 58237636[3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58288517[3-(2-Methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 3, Step 2, using the following starting materials: [3-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester and methylamine (2M in THF).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-dd98911e7c354b9e96b9e786a032ea98
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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