Benzyl chloroformate → (3-{2-[(Benzyloxycarbonyl-methyl-amino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

HRID 1969058Notes

Reaction equation

HRID 1969058 reaction equation
[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH3:24])[CH:6]=1.Cl[C:27]([O:29][CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=1)=[O:28]>>[CH3:1][O:2][C:3](=[O:25])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([C:27]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[O:28])[CH3:24])[CH:6]=1

Participants

3

Reactant 2

HCID 10387Benzyl chloroformateHCID 58288517[3-(2-Methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

Product 1

HCID 58288520(3-{2-[(Benzyloxycarbonyl-methyl-amino)-methyl]-4-trifluoromethyl-phenoxy}-phenyl)-acetic acid methyl ester

Procedure

Prepared according to the procedure described in Example 3, Step 3, using the following starting materials: [3-(2-methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester and benzyl chloroformate.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-8e328abf90f042d49923ec7162da19f7
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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