Methylamine → [3-(2-Methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid

HRID 1969060Notes

Reaction equation

HRID 1969060 reaction equation
[CH:1]([C:3]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:4]=1[O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1)=O.[CH3:24][NH2:25]>>[CH3:24][NH:25][CH2:1][C:3]1[CH:19]=[C:18]([C:20]([F:23])([F:22])[F:21])[CH:17]=[CH:16][C:4]=1[O:5][C:6]1[CH:7]=[C:8]([CH2:12][C:13]([OH:15])=[O:14])[CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 58237662[3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid

Product 1

HCID 58288535[3-(2-Methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid

Procedure

Prepared according to the procedure described in Example 3, Step 2, using the following starting materials: [3-(2-formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid and methylamine (2M in THF)

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3238aa7e16e54c13807fb52967b153dc
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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