4-Chlorobenzenesulfonyl chloride → [3-(2-{[(4-Chloro-benzenesulfonyl)-methyl-amino]-methyl}-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid

HRID 1969061Notes

Reaction equation

HRID 1969061 reaction equation
[CH3:1][NH:2][CH2:3][C:4]1[CH:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][C:5]=1[O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14]([OH:16])=[O:15])[CH:10]=[CH:11][CH:12]=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([S:32](Cl)(=[O:34])=[O:33])=[CH:28][CH:27]=1>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([S:32]([N:2]([CH2:3][C:4]2[CH:20]=[C:19]([C:21]([F:23])([F:22])[F:24])[CH:18]=[CH:17][C:5]=2[O:6][C:7]2[CH:8]=[C:9]([CH2:13][C:14]([OH:16])=[O:15])[CH:10]=[CH:11][CH:12]=2)[CH3:1])(=[O:34])=[O:33])=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 73984-Chlorobenzenesulfonyl chlorideHCID 58288535[3-(2-Methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid

Product 1

HCID 44539244[3-(2-{[(4-Chloro-benzenesulfonyl)-methyl-amino]-methyl}-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid

Procedure

Prepared according to the procedure described in Example 22, Step 1, using the following starting materials: [3-(2-methylaminomethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid and 4-chlorobenzenesulfonyl chloride. M+H=514.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-3e79c330782c4ceda368105d2903b58c
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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