HRID1969091

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

HCID58288509

未命名化合物

PRODUCTS

产物

HCID44538033

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID962

Water

H2O

CONDITIONS

反应条件

温度: 60 °C

PROCEDURE

实验过程

To a solution of {3-[2-[(benzyloxycarbonyl-ethyl-amino)-methyl]-4-(4-chloro-benzoylamino)-phenoxy]-4-methoxy-phenyl}-acetic acid ethyl ester (0.18 mmol) in MeOH and H2O was added lithium hydroxide (0.100 g, 2.4 mmol), and the reaction was stirred at 60° C. for 20 minutes. After work-up, the crude material was purified by preparative HPLC to give the title compound. M+H=603.

WORKUP

后处理

customAfter work-up, the crude material was purified by preparative HPLC

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-da1f46ed305b44be87757bae4cf9cd0f
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08426449B2
来源说明: uspto-grants-2013_04

反应SMILES

C([O:3][C:4](=[O:45])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([NH:21][C:22](=[O:30])[C:23]3[CH:28]=[CH:27][C:26]([Cl:29])=[CH:25][CH:24]=3)=[CH:17][C:16]=2[CH2:31][N:32]([C:35]([O:37][CH2:38][C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[O:36])[CH2:33][CH3:34])[CH:7]=1)C.[OH-].[Li+]>CO.O>[CH2:38]([O:37][C:35]([N:32]([CH2:31][C:16]1[CH:17]=[C:18]([NH:21][C:22](=[O:30])[C:23]2[CH:24]=[CH:25][C:26]([Cl:29])=[CH:27][CH:28]=2)[CH:19]=[CH:20][C:15]=1[O:14][C:8]1[CH:7]=[C:6]([CH2:5][C:4]([OH:45])=[O:3])[CH:11]=[CH:10][C:9]=1[O:12][CH3:13])[CH2:33][CH3:34])=[O:36])[C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1