Triethylamine → HCID 66995399, compound

HRID 1969152Notes

Reaction equation

HRID 1969152 reaction equation
[SH:1][CH2:2][C:3]([O:5][CH2:6][CH3:7])=[O:4].C(N(CC)CC)C.[C:15]([C:17](=[N:28]OS(C1C=CC(C)=CC=1)(=O)=O)[C:18]1[CH:19]=[CH:20][C:21]([O:26][CH3:27])=[C:22]([CH:25]=1)[C:23]#[N:24])#[N:16]>C(O)C>[NH2:16][C:15]1[C:17]([C:18]2[CH:19]=[CH:20][C:21]([O:26][CH3:27])=[C:22]([C:23]#[N:24])[CH:25]=2)=[N:28][S:1][C:2]=1[C:3]([O:5][CH2:6][CH3:7])=[O:4]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12185Ethyl ThioglycolateHCID 86626139HCID 86626139, compound

Product 1

HCID 66995399HCID 66995399, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl sulfanylacetate and triethylamine were dissolved in an ethanol solution of 5-[cyano({[(4-methylphenyl)sulfonyl]oxy}imino)methyl]-2-methoxybenzonitrile, followed by stirring for 5 hours under ice-cooling to obtain ethyl 4-amino-3-(3-cyano-4-methoxyphenyl)isothiazole-5-carboxylate. AP: 378.

Workup

  1. temperaturecooling

Sources & evidence

ORD record
ord-c8b29c7fb01c4fd9b6d19c44f0147b16
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Reaction notes

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