HCID 726575, compound → HCID 59588990, compound

HRID 1969328Notes

Reaction equation

HRID 1969328 reaction equation
Br[CH2:2]/[C:3](/[F:15])=[C:4](/[CH3:14])\[CH2:5][NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10].[CH:16]1([NH:22][C:23](=[O:31])[C:24]2[CH:29]=[CH:28][C:27]([OH:30])=[CH:26][CH:25]=2)[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[CH:16]1([NH:22][C:23]([C:24]2[CH:29]=[CH:28][C:27]([O:30][CH2:2]/[C:3](/[F:15])=[C:4](/[CH3:14])\[CH2:5][NH:6][C:7](=[O:13])[O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[CH:26][CH:25]=2)=[O:31])[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1

Participants

3

Reactant 2

HCID 726575HCID 726575, compoundHCID 59588959HCID 59588959, compound

Product 1

HCID 59588990HCID 59588990, compound

Procedure

This compound was synthesized from tert-butyl [(2E)-4-bromo-3-fluoro-2-methylbut-2-en-1-yl]carbamate and N-cyclohexyl-4-hydroxybenzamide following procedure F and was obtained as a colorless solid; 1H-NMR (400 MHz, CDCl3): δppm: 1.15-1.27 (3H, m), 1.37-1.48 (2H, m), 1.43 (9H, s), 1.62-1.67 (1H, m), 1.72-1.77 (2H, m), 1.76 (3H, d, J 4.0 Hz), 2.00-2.04 (2H, m), 3.77 (2H, d, J 5.7 Hz), 3.95 (1H, m), 4.61 (1H, br s), 4.75 (2H, d, J 21.4 Hz), 5.85 (1H, br s), 6.95 (2H, d, J 9.0 Hz), 7.72 (2H, d, J 9.0 Hz).

Workup

  1. customwas obtained as a colorless solid

Sources & evidence

ORD record
ord-c0afce67c8de4f66becb4c75e56afb95
Source dataset
uspto-grants-2013_04
Patent number
US08426587B2

Reaction notes

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