反应详情

The title compound was prepared according to the procedure described in Example 9 by using N-(5-(7-hydroxyquinolin-4-yloxy)pyridin-2-yl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (277 mg, 0.593 mmol), Cs2CO3 (560 mg, 1.724 mmol, Aladdin), and 3-(1-hydroxycyclopropyl)propyl methanesulfonate (334 mg, 1.724 mmol) in DMA (10 mL). The title compound was purified by a silica gel column chromatography (67:30:1:2 (v/v/v/v) EtOAc/CH2Cl2/CH3OH/Et3N) to afford the title compound as a white solid (210 mg, 62.6%).

1. customThe title compound was prepared
2. customThe title compound was purified by a silica gel column chromatography (67:30:1:2 (v/v/v/v) EtOAc/CH2Cl2/CH3OH/Et3N)