Hydrochloric Acid → 6-(2-Aminopropan-2-yl)pyridine-2-carbonitrile--hydrogen chloride (1/1)

HRID 1969457Notes

Reaction equation

HRID 1969457 reaction equation
[ClH:1].O1CCOCC1.C(OC(=O)[NH:14][C:15]([C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]#[N:25])[N:19]=1)([CH3:17])[CH3:16])(C)(C)C>>[ClH:1].[NH2:14][C:15]([C:18]1[N:19]=[C:20]([C:24]#[N:25])[CH:21]=[CH:22][CH:23]=1)([CH3:16])[CH3:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 58129454HCID 58129454, compound

Product 1

HCID 665706716-(2-Aminopropan-2-yl)pyridine-2-carbonitrile--hydrogen chloride (1/1)Yield 97%

Procedure

Add 4N HCl in dioxane (17 mL, 68 mmol) to [1-(6-cyano-pyridin-2-yl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (1.2 g, 5 mmol). Stir the solution at room temperature for 10 minutes and observe the formation of a white solid. Stir the reaction at room temperature for 4 hours. Evaporate the solvent to give 6-(1-amino-1-methyl-ethyl)-pyridine-2-carbonitrile hydrochloride salt as a white solid (880 mg, 97% yield).

Workup

  1. stirringStir
  2. customthe reaction at room temperature for 4 hours
  3. customEvaporate the solvent

Sources & evidence

ORD record
ord-669d0734bf12401380159e4e99adbc84
Source dataset
uspto-grants-2013_04
Patent number
US08426448B2

Reaction notes

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