反应详情

Under argon, 220 mg of the mixture from Example 22A were initially charged in 10 ml of ethyl acetate, 110 mg of palladium (10% on activated carbon) were added and the mixture was hydrogenated at atmospheric hydrogen pressure and room temperature overnight. The catalyst was filtered off through Celite, the filter cake was washed with ethyl acetate and the filtrate was concentrated. The residue was purified by preparative HPLC. This gave 31 mg (17% of theory) of the target compound.

1. filtrationThe catalyst was filtered off through Celite
2. washthe filter cake was washed with ethyl acetate
3. concentrationthe filtrate was concentrated
4. customThe residue was purified by preparative HPLC