Hydrochloric Acid → HCID 67216964, compound

HRID 1969523Notes

Reaction equation

[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][NH:15]C(OC(C)(C)C)=O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:23]>>[ClH:23].[CH2:1]([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][NH2:15])[CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 58557648HCID 58557648, compound

Product 1

HCID 67216964HCID 67216964, compoundYield 146.3%

Procedure

A solution of tert-butyl 2-(1-benzylpiperidin-3-yl)hydrazinecarboxylate (1.25 g, 4.10 mmol) in aqueous HCl (6 N, 6.83 mL, 41.0 mmol) was stirred at ambient temperature for about 8 h. The solvent was removed under reduced pressure to give crude 1-benzyl-3-hydrazinylpiperidine hydrochloride (1.45 g, 112%) as a white solid which was used without further purification: LC/MS (Table 1, Method b) Rt=0.66 min; MS m/z: 206 (M+H)+.

Workup

customThe solvent was removed under reduced pressure

Sources & evidence

ORD record: ord-10126ee409f24758a6d36eb2ca528a24
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08426411B2

Reaction notes

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