反应详情

To a solution of (S)-2-methyl-N-(2,2,2-trifluoro-1-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)ethyl)propane-2-sulfinamide (1.40 g, 2.95 mmol) in MeOH (20 mL) was added HCl (4 N in 1,4-dioxane, 7.38 mL, 29.5 mmol). After about 2 h, the reaction mixture was partially concd in vacuo and diluted with Et2O until solids began to form. After about 30 min, the resulting solids were collected by filtration and dried in vacuo to provide 2,2,2-trifluoro-1-(5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-yl)ethanamine hydrochloride (0.840 g, 70%) as a solid. LC/MS (Table 1, Method a) Rt=2.16 min; MS m/z 371 (M+H)+.

1. customto form
2. waitAfter about 30 min
3. filtrationthe resulting solids were collected by filtration
4. customdried in vacuo