Morpholine → HCID 86627484, compound

HRID 1969958Notes

Reaction equation

HRID 1969958 reaction equation
Cl[S:2]([C:5]1[CH:14]=[CH:13][C:12]2[NH:11][C:10](=[O:15])[C:9]3[NH:16][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[C:8]=3[C:7]=2[CH:6]=1)(=[O:4])=[O:3].[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>CO>[N:22]1([S:2]([C:5]2[CH:14]=[CH:13][C:12]3[NH:11][C:10](=[O:15])[C:9]4[NH:16][CH:17]=[CH:18][C:8]=4[C:7]=3[CH:6]=2)(=[O:3])=[O:4])[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1.[CH2:18]([C:19]([O-:21])=[O:20])[CH3:17]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 451210688-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid

Product 1

HCID 86627484HCID 86627484, compoundYield 8.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

This compound is prepared according to synthesis 25, from 115 mg (0.30 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 32 μL (0.36 mmol) of morpholine. After trituration in hot methanol, 5 mg (4%) of 8-(morpholine-4-sulfonyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a gray solid.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-234f5ae0978b45bf8d88d6eea961f2af
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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