Methanesulfonyl chloride → HCID 86627490, compound

HRID 1969965Notes

Reaction equation

HRID 1969965 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[C:6]3[NH:13][CH:14]=[CH:15][C:5]=3[C:4]=2[CH:3]=1.[CH2:16]([C:18]([O-:20])=[O:19])[CH3:17].[CH3:21][S:22](Cl)(=[O:24])=[O:23]>>[CH3:21][S:22]([NH:1][C:2]1[CH:11]=[CH:10][C:9]2[NH:8][C:7](=[O:12])[C:6]3[NH:13][CH:14]=[CH:15][C:5]=3[C:4]=2[CH:3]=1)(=[O:24])=[O:23].[CH2:16]([C:18]([O-:20])=[O:19])[CH3:17]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 86627489HCID 86627489, compound

Product 1

HCID 86627490HCID 86627490, compoundYield 46%

Procedure

This compound is prepared according to synthesis 37, from 50 mg (0.18 mmol) of 8-amino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate (synthesis 64) and 17 μL (0.20 mmol) of methanesulfonyl chloride. After recrystallization from methanol, 29 mg (45%) of 8-methanesulfonylamino-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate is obtained in the form of a white solid.

Workup

  1. customThis compound is prepared
  2. customAfter recrystallization from methanol

Sources & evidence

ORD record
ord-13fbae93521f4e4db2cef0b414f8980c
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

Loading…