4-Methylmorpholine → HCID 57575961, compound

HRID 1970002Notes

Reaction equation

HRID 1970002 reaction equation
[O:1]=[C:2]1[C:11]2[NH:12][CH:13]=[C:14]([C:15]([OH:17])=O)[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[NH:3]1.[CH3:18][N:19]1CCOCC1.Cl.CN>C(OCC)C>[CH3:18][NH:19][C:15]([C:14]1[C:10]2[C:9]3[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=3[NH:3][C:2](=[O:1])[C:11]=2[NH:12][CH:13]=1)=[O:17]

Participants

5

Reactant 3

HCID 79724-MethylmorpholineHCID 6364545Methylamine hydrochlorideHCID 120650844-oxo-3H,4H,5H-pyrrolo[2,3-c]quinoline-1-carboxylic acid

Product 1

HCID 57575961HCID 57575961, compoundYield 7.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This compound is prepared according to synthesis 79 from 37 mg (0.17 mmol) of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 75), 108 μL (0.99 mmol) of N-methylmorpholine and 17 mg (0.25 mmol) of methylamine hydrochloride. After trituration in diethyl ether, 3 mg (7%) of N-(methyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxamide are obtained in the form of a light brown solid.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-2f3b255b234848bd9a17530ff9899b57
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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