1-Methylpiperazine → HCID 68564597, compound

HRID 1970005Notes

Reaction equation

HRID 1970005 reaction equation
Cl[S:2]([C:5]1[CH:14]=[CH:13][C:12]2[NH:11][C:10](=[O:15])[C:9]3[NH:16][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[C:8]=3[C:7]=2[CH:6]=1)(=[O:4])=[O:3].[CH3:22][N:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1>>[CH3:22][N:23]1[CH2:28][CH2:27][N:26]([S:2]([C:5]2[CH:14]=[CH:13][C:12]3[NH:11][C:10](=[O:15])[C:9]4[NH:16][CH:17]=[C:18]([C:19]([OH:21])=[O:20])[C:8]=4[C:7]=3[CH:6]=2)(=[O:4])=[O:3])[CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 531671-MethylpiperazineHCID 451210688-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid

Product 1

HCID 68564597HCID 68564597, compound

Procedure

8-(4-Methyl-piperazine-1-sulfonyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid is prepared according to synthesis 25, from 440 mg (0.75 mmol) of 8-chlorosulfonyl-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid (synthesis 2) and 164 μl (1.48 mmol) of 1-methyl-piperazine to give, after washing with water, 340 mg (65%) of 8-(4-methyl-piperazine-1-sulfonyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a white solid.

Workup

  1. customto give
  2. washafter washing with water, 340 mg (65%) of 8-(4-methyl-piperazine-1-sulfonyl)-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a white solid

Sources & evidence

ORD record
ord-7538d50fe3d94b228893d7420956ba97
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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