Acetyl chloride → HCID 86627523, compound

HRID 1970008Notes

Reaction equation

HRID 1970008 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][C:8](=[O:13])[CH2:7]2)(=[O:3])[CH3:2].[NH:14]1C2[C:17](=CC=CC=2)[CH2:16][C:15]1=[O:23].[Cl-].[Cl-].[Cl-].[Al+3].C(Cl)(=[O:30])C>>[C:1]([C:4]1[CH:12]=[CH:11][C:10]2[NH:9][C:8](=[O:13])[C:7]3[NH:14][CH:15]=[CH:16][C:17]=3[C:6]=2[CH:5]=1)(=[O:3])[CH3:2].[CH2:16]([C:15]([O-:23])=[O:30])[CH3:17]

Participants

5

Reactant 4

HCID 6367Acetyl chlorideHCID 321710OxindoleHCID 6451240Aluminum(III) ChlorideHCID 102196435-acetyl-2,3-dihydro-1H-indol-2-one

Product 1

HCID 86627523HCID 86627523, compound

Procedure

Synthesis of 5-acetyl-1,3-dihydro-indol-2-one is described by Peng Cho Tang (US2003/0069421 A1). This compound was prepared according to this procedure from 6.65 g (50 mmol) of 1,3-dihydro-indol-2-one, aluminium trichloride (150 mmol) and acetyl chloride (100 mmol) to give, after trituration in water and drying, 7.32 g (83%) of 5-acetyl-1,3-dihydro-indol-2-one in the form of a beige solid.

Workup

  1. customThis compound was prepared
  2. customto give
  3. dry with materialafter trituration in water and drying

Sources & evidence

ORD record
ord-a7cf9bd9a6bb4db588a2ac7731b4f0e0
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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