Benzoyl chloride → HCID 86627524, compound

HRID 1970009Notes

Reaction equation

HRID 1970009 reaction equation
[C:1]([C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][C:13](=[O:18])[CH2:12]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:19]1C2[C:22](=CC=CC=2)[CH2:21][C:20]1=[O:28].[Cl-].[Cl-].[Cl-].[Al+3].[C:33](Cl)(=[O:40])[C:34]1[CH:39]=CC=CC=1>>[C:1]([C:9]1[CH:17]=[CH:16][C:15]2[NH:14][C:13](=[O:18])[C:12]3[NH:19][CH:20]=[CH:21][C:22]=3[C:11]=2[CH:10]=1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[CH2:34]([C:33]([O-:40])=[O:28])[CH3:39]

Participants

5

Reactant 4

HCID 7412Benzoyl chlorideHCID 321710OxindoleHCID 6451240Aluminum(III) ChlorideHCID 134081645-Benzoyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 86627524HCID 86627524, compound

Procedure

Synthesis of 5-benzoyl-1,3-dihydro-indol-2-one is described by McNutt (WO99/10325). This compound was prepared according to this procedure from 665 g (5 mmol) of 1,3-dihydro-indol-2-one, aluminium trichloride (15 mmol) and benzoyl chloride (10 mmol) to give, after trituration in water and drying, 880 mg (74%) of 5-benzoyl-1,3-dihydro-indol-2-one in the form of a beige solid.

Workup

  1. customThis compound was prepared
  2. customto give
  3. dry with materialafter trituration in water and drying

Sources & evidence

ORD record
ord-b4a47cf161944e5da39d7a75c6b7b09f
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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