Lithium hydroxide, monohydrate → HCID 57576069, compound

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Reaction Steps

This compound is prepared according to synthesis 75 from 412 mg (0.93 mmol) of 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate and 360 mg (13.95 mmol) of lithium hydroxide monohydrate to give, after acid-basic treatment and precipitation in an acid aqueous phase (pH 5), 200 mg (52%) of 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a pale pink solid.

Provenance & Evidence