Lithium hydroxide, monohydrate → HCID 57576069, compound

HRID 1970010Notes

Reaction equation

HRID 1970010 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]([CH3:26])[S:9]([C:12]2[CH:21]=[CH:20][C:19]3[NH:18][C:17](=[O:22])[C:16]4[NH:23][CH:24]=[CH:25][C:15]=4[C:14]=3[CH:13]=2)(=[O:11])=[O:10])=[CH:4][CH:3]=1.C([C:29]([O-:31])=[O:30])C.O.[OH-].[Li+]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([N:8]([CH3:26])[S:9]([C:12]2[CH:21]=[CH:20][C:19]3[NH:18][C:17](=[O:22])[C:16]4[NH:23][CH:24]=[C:25]([C:29]([OH:31])=[O:30])[C:15]=4[C:14]=3[CH:13]=2)(=[O:11])=[O:10])=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 86627470HCID 86627470, compound

Product 1

HCID 57576069HCID 57576069, compound

Procedure

This compound is prepared according to synthesis 75 from 412 mg (0.93 mmol) of 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-ethyl carboxylate and 360 mg (13.95 mmol) of lithium hydroxide monohydrate to give, after acid-basic treatment and precipitation in an acid aqueous phase (pH 5), 200 mg (52%) of 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a pale pink solid.

Workup

  1. customThis compound is prepared
  2. customto give
  3. customafter acid-basic treatment and precipitation in an acid aqueous phase (pH 5), 200 mg (52%) of 8-[(4-fluorophenyl)-methyl-sulfamoyl]-4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid in the form of a pale pink solid

Sources & evidence

ORD record
ord-9ccdafa282144040b8c9e69035c83c2e
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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